ALK and esophageal squamous cell carcinoma: In addition to the EML4-ALK fusion gene in lung cancer, various ALK-related diseases have been reported, including familial neuroblastoma [10], renal cell carcinomas [11,12,13,14], esophageal squamous cell carcinomas [15,16], breast cancer, colonic adenocarcinomas [17], glioblastoma multiforme [18,19], and anaplastic thyroid cancer [20].