Given the contention that findings from transplantable tumor models may not provide the most useful information for translation into the clinic, we next evaluated a genetically engineered inducible BrafV600E/Pten-driven melanoma murine model that is more reflective of human disease (e.g., tumor self Ag expression, highly metastatic, and relapses post chemotherapies).31 This evidence concerns the gene RENBP and melanoma.