CD14 and cancer: Although it remains to be determined whether HLA-DR+CD14+IL-15+/IL-15Rα+ DC that emigrate out of human skin explants after genetic-immunization using this vaccine strategy promote the differentiation of melanoma Ag-specific CD8+ T cells in vitro and in humanized (human melanoma-bearing severe combined immunodeficiency) mice, our current data support the notion that this approach could be used to potentiate human skin DC for the effective genetic immunization against cancer.