Although it remains to be determined whether HLA-DR+CD14+IL-15+/IL-15Rα+ DC that emigrate out of human skin explants after genetic-immunization using this vaccine strategy promote the differentiation of melanoma Ag-specific CD8+ T cells in vitro and in humanized (human melanoma-bearing severe combined immunodeficiency) mice, our current data support the notion that this approach could be used to potentiate human skin DC for the effective genetic immunization against cancer. The gene discussed is CD8A; the disease is cancer.