It remains to be clarified whether the tolerogenic LL-DC (low lipid DC) population is equivalent with the same immunoregulatory DCs in NASH as described by Henning et al. Of note, based on the surface marker expression profile of HL-DCs and LL-DCs, they rather seemed to be a part of a heterogeneous population, despite that all cells expressed various level of CD11c (43). This evidence concerns the gene ITGAX and metabolic dysfunction-associated steatohepatitis.