Overall, we found that medium-to-long-term oxytocin administration combined with psychotherapy does not seem to affect symptomatic depression, but it does more subtly affect the depressive presentation of the mothers: the therapists double-blindly perceived the mothers as being still depressed but less self-centered (or showing a less narcissistic pattern of behavior with their therapist and possibly with their child). This evidence concerns the gene OXT and major depressive disorder.