Based on the above data, the involvement of BK channels in GBM cell migration, more than on the cell migration mode (2D vs. 3D), appears to primarily depend on the features of the Ca2+ signals (i.e., steady vs. oscillatory), and ultimately on the degree and mode (again, steady vs. oscillatory) of BK channel activation. Here, KCNMA1 is linked to glioblastoma.