Unfortunately, paxilline has also been shown to inhibit the endoplasmic reticulum Ca-ATPase (SERCA; IC50 of 5–50 μM depending on the specific type of the transporter; Bilmen et al., 2002) and to sensitize the TRAIL (TNF-related apoptosis-inducing ligand)-induced GBM cell death, an effect mimed by other SERCA inhibitors, but not by other BK channel inhibitors (Kang et al., 2011). Here, TNFSF10 is linked to glioblastoma.