We found elevated mRNA levels of RhoA (3.02-fold, p = 0.0323), ROCK1 (2.58-fold, p = 0.0081), PRK2 (3.22-fold, p = 0.0049), Profilin1 (3.53-fold, p = 0.0267), MYPT1 (2.85-fold, p = 0.019) in postmortem brain of individuals with HD compared with controls (Fig. 1b), suggesting that Rho kinase pathway genes are similarly altered in the postmortem HD brain tissues. Here, PKN2 is linked to Huntington disease.