We found elevated mRNA levels of RhoA (3.02-fold, p = 0.0323), ROCK1 (2.58-fold, p = 0.0081), PRK2 (3.22-fold, p = 0.0049), Profilin1 (3.53-fold, p = 0.0267), MYPT1 (2.85-fold, p = 0.019) in postmortem brain of individuals with HD compared with controls (Fig. 1b), suggesting that Rho kinase pathway genes are similarly altered in the postmortem HD brain tissues. This evidence concerns the gene PPP1R12A and Huntington disease.