ROCK1 and Huntington disease: We found elevated mRNA levels of RhoA (3.02-fold, p = 0.0323), ROCK1 (2.58-fold, p = 0.0081), PRK2 (3.22-fold, p = 0.0049), Profilin1 (3.53-fold, p = 0.0267), MYPT1 (2.85-fold, p = 0.019) in postmortem brain of individuals with HD compared with controls (Fig. 1b), suggesting that Rho kinase pathway genes are similarly altered in the postmortem HD brain tissues.