In our studies, we found that knockdown of H3R expression suppressed the expression EMT-activators (Twist, Slug and Snail) and restored the expression of epithelial cell markers (E-cadherin and ZO-1) while blockade of its activity down-regulated the expression of mesenchymal cell markers (N-cadherin and Vimentin) in glioma U87MG cells. This evidence concerns the gene HRH3 and central nervous system cancer.