Either knockdown or blockade of the PI3K/Akt or MEK/ERK signaling pathways inhibited RAMH-mediated increase in cell invasion and reorganization of the cadherin-household, confirming that PI3K/Akt and MEK/ERK signaling pathways play a role in the H3R-mediated tumor invasion and EMT progression. Here, HRH3 is linked to neoplasm.