Overexpression of LCN2 promotes mesenchymal-like cell morphology accompanied by loss of epithelial marker (E-cadherin) and increased expression of mesenchymal markers (vimentin, fibronectin and MMPs) that contribute to invasiveness [12, 13], which accounts for their roles in enhancing tumor cell motility for metastasis. The gene discussed is LCN2; the disease is neoplasm.