In this study, we found that a high EMP2 protein level could be an independent prognostic factor for DSS in UBUC patients, suggesting that loss of EMP2 expression plays a crucial role in the mortality of UBUC, similar to its role in nasopharyngeal carcinoma [24] and UTUC [12] observed in our earlier studies. This evidence concerns the gene EMP2 and renal pelvis/ureter urothelial carcinoma.