In addition we found that, presence of EGFR instead of ErbB2 in the triple oncogene combination potentially drives an early lung metastasis and give unique liver metastasis from same cellular precursor i.e K5+/K19− (Table 3, Supplementary Table 4) suggesting the significant effect of an oncogene on pathogenicity of tumor. The gene discussed is KRT5; the disease is neoplasm.