On the other hand, we observed K5+/K19+ cell line over-expressing mRas/mp53/wtEGFR had a low primary tumor latency as compared to K5+/K19− with same oncogene combination (Figure 5A, Tables 1, 2, Supplementary Table 2) and high tumor incidence (Supplementary Table 5) as compared to all other cell lines tested. Here, KRT5 is linked to neoplasm.