DACH1 and neoplasm: However, DACH1 occupies a more prominent role in the prognosis of HCC patients compared with Ki-67 index, since endogenous expression of DACH1 might not only be responsible for the inhibition of malignant proliferation, but also interact with other cytokines in tumor microenvironment like IL-8 [12] or CXCL5 [34].