However, DACH1 expression could drastically reduce at early stage of HCC, and even dysplastic changes was tightly correlated with downregulation of DACH1, indicating the analysis of DACH1 might be useful for the potential screening for the super high-risk population of HCC by liver biopsy in patients with chronic hepatitis or other benign lesion. This evidence concerns the gene DACH1 and chronic hepatitis.