Cyclin D1 is overexpressed in the majority of human breast tumors, many of these representing downstream effects through induction of cyclin D1 by oncogenic signals (Ras, MAPK [39]), Src [40], ErbB2 [41], STATs [42], Notch [43], NFκB [44]. The gene discussed is NFKB1; the disease is breast neoplasm.