Examples of diseases that have been associated with HLA molecules include: ankylosing spondylitis with HLA-B*27; type 1 autoimmune hepatitis with HLA-DRB1*03:01 and HLA-DRB1*04:01; insulin-dependent type 1 diabetes mellitis and celiac disease with HLA-DQB1*03:02; primary biliary cirrhosis, neuromyelitis optica, and cervical cancer with HLA-DQB1*04:02; and anti-citrullinated antibody positive rheumatoid arthritis with HLA-C*03:04 [15-21]. This evidence concerns the gene HLA-B and neuromyelitis optica.