Mechanism dissection indicated that the miR301a promoted breast cancer proliferation and metastasis via targeting FOXF2, BBC3, PTEN, and COL2A1 [18], as well as down-regulated NF-kB-repressing factor and elevated NF-kB activation in human pancreatic adenocarcinoma [29]. This evidence concerns the gene COL2A1 and pancreatic adenocarcinoma.