As shown in Fig. 3E–3F, the sensitizing effect of S100A11 silencing was similar in NSCLC A549 cells expressing wild type (wt) p53 and U1810 cells with p53 containing a frameshift mutation in the central p53 DNA-binding domain [39], referred to as not functional [40]. This evidence concerns the gene TP53 and non-small cell lung carcinoma.