CASP3 and non-small cell lung carcinoma: Moreover, the sensitizing effect of S100A11 silencing was not specific to the A549 cells, since similar and even more pronounced chemosensitization was observed in another NSCLC cell line, U1810, as evaluated by the increased level of cleaved PARP (Fig. 3E), and an increase in caspase-3-like activity (Fig. 3F).