Since Dicer silencing did not affect NSCLC sensitivity to cisplatin in a manner similar to TSN silencing in all three tested NSCLC cell lines (A549, H661 and U1810), we hypothesized that the role of TSN in NSCLC resistance to cisplatin was likely not related to its role in RNA interference machinery, but was rather mediated by transcriptional changes regulated by TSN. This evidence concerns the gene TSN and non-small cell lung carcinoma.