CLU and Alzheimer disease: Further to the role in cerebral amyloid angiopathy (CAA) and AD, clusterin may be involved in pathological changes in cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL), the most common type of hereditary small vessel disease (SVD), caused by mutations in the NOTCH3 gene [12, 13].