In this article we describe the screening of a panel of HCM-affected probands for TNNI3, a gene that has been associated not only with HCM but also with dilated cardiomyopathy and RCM.4 The screening was performed because two unrelated individuals, referred with HCM, had features resembling that of RCM. This evidence concerns the gene TNNI3 and dilated cardiomyopathy.