However, during multivariate logistic regression analysis, after adjusting for age, SES, HAART exposure, smoking, excessive alcohol intake, waist circumference, CD4+ T-cell counts and plasma HIV loads, H pylori seropositivity (constant B = 5.2; SE = 1.114; wald χ2 = 21.785; OR = 13.5, 95% CI: 10.3–17.6; p < 0.0001) and peripheral obesity (median hip circumference ≥ 97 cm) (constant B = 1.545; SE = 0.708; wald χ2 = 4.756; OR = 4.7, 95% CI: 1.2–18.8; p = 0.029) were identified as the only factors significantly associated with the MetS in HIV-infected patients. This evidence concerns the gene CD4 and metabolic syndrome.