We compared co-localization of endogenous ubiquitin and transiently expressed GFP–LRRK2 and LRRK2 [G2019S] in the presence and absence of GNE1023, as well as PD-related variants of LRRK2 [S910/935A, R1441G, Y1699C and I2020T]. The gene discussed is LRRK2; the disease is Parkinson disease.