KMO and Dyskinesia: Blockade with 3,4-dimethoxy-N-[4-(3-nitrophenyl)thiazol-2-yl]benzenesulfonamide (Ro-61-8048), a potent KMO inhibitor, results in increased KYNA content in parkinsonian monkeys, and when combined with levodopa, it reduces the severity of dyskinesias, both acutely and after prolonged administration [124,125].