ACE and hypertensive disorder: Calcium blockers decrease the risk of cardiovascular events as well as ACE inhibitors or ARBs in type 2 diabetic patients with hypertension [20, 24–28] and previous study showed that a combination of olmesartan and azelnidipine improved HbA1c level significantly [29] and azelnidipine significantly decreased levels of glucose and insulin 120 min after the 75 g oral glucose tolerance test [30].