Subsequently, elevated levels of TNF-α, IFN-γ and, IL-6 were reported in DENV-infected AG129 mice following inoculation with the non-mouse-adapted DENV-2 strain D2Y98P [21], and all four cytokines were also shown to be elevated in ADE models of severe DENV-2 disease [15, 17, 25]. This evidence concerns the gene TNF and acute disseminated encephalomyelitis.