In a recent study by Lovren et al in experimental atherosclerosis it was demonstrated that targeted delivery of miRNA-145 into VSMCs in Apolipoprotein E knockout mice (ApoE-/-) was associated with markedly reduced plaque size, significantly increased fibrous cap area and plaque collagen content, and reduced necrotic core area at 12 weeks [32]. The gene discussed is APOE; the disease is atherosclerosis.