In ING5-overexpressed A549 cells, we detected an increased expression of E-cadherin which is a hallmark of EMT and often lost in metastatic tumors [19], while the expression of SNAIL, Slug and N-cadherin was downregulated, suggesting that ING5 inhibit lung cancer cell invasion by suppressing EMT. This evidence concerns the gene ING5 and metastatic neoplasm.