Systemic IL1β as a result of oral cavity Pg infection, in association with Pg-mediated enhanced CD36/SR-B2-oxidized LDL (oxLDL) macrophage lipid uptake and inhibition of pyroptosis in the vasculature, may be key to enhanced atherosclerosis in PD and present novel potential targets for development of treatment strategies. This evidence concerns the gene MED20 and atherosclerosis.