Reduction of gene expression was significantly correlated in all three pairwise combinations in cancer tissues, namely hMLH1 and hMSH2 (r = 0.97, P value<0.001), hMSH2 and hMSH6 (r = 0.9, P value<0.001) as well as hMSH6 and hMLH1 (r = 0.94, P value<0.001) in cancer tissues (Fig 1C, upper panel). This evidence concerns the gene MSH6 and cancer.