A semi-quantitative densitometric measurements of band intensities from the Western blot assays confirmed the down-regulation of hMLH1 (2.02 fold, P value<0.01), hMSH6 (2 fold, P value<0.01) and hMSH2 (1.95 fold, P value<0.05) proteins in tumor samples (n = 6) in comparison with BPH samples (n = 6) (Fig 1D). The gene discussed is MSH2; the disease is neoplasm.