hMSH6 Pro92Pro polymorphism (rs1800932) showed a protective effect for tumors in the colorectum and colon in patients with Swedish origin (n = 1103 for colon cancer, n = 637 for rectal cancer, and n = 436 for controls) with the rare allele being associated with increased levels of mRNA and ovarian aging [79, 80]. This evidence concerns the gene MSH6 and rectal cancer.