We reviewed seven meta-analyses and found that subjects with the XRCC1 Arg194Trp Arg/Trp + Trp/Trp genotype had a 1.2-fold (1.02–1.41) increased OR (95%CI) of bladder cancer compared to those with the Arg/Arg genotype [18,40]. This evidence concerns the gene XRCC1 and urinary bladder carcinoma.