Multivariate analysis demonstrated that PgR was independently associated with older age (hazard ratio [HR], 2.48; 95% confidence interval [CI], 1.931–3.185; P < 0.0001), grade III tumours (HR, 2.118; 95% CI, 1.581–2.839, P < 0.0001), larger tumours (≥5 cm, HR, 4.831; 95% CI, 1.664–14.024, P = 0.004), tumours in pN3 (HR, 2.002; 95% CI, 1.021–3.922, P = 0.043) and high Ki-67 (HR, 1.391; 95% CI, 1.046–1.850; P = 0.023). This evidence concerns the gene PGR and neoplasm.