CD4 and premature menopause: Proportions of CD4+ T lymphocytes on days 1, 3 and 7 were significantly decreased in POF patients compared with TOF patients (27.73 ± 8.25% vs. 37.26 ± 7.04%, 31.81 ± 7.87% vs. 40.79 ± 7.07% and 33.55 ± 9.31% vs. 42.61 ± 7.81%, P < 0.0001).