Serum peak value of IL-6 was observed on day 1, and then decreased rapidly on days 3 and 7 in both POF patients (63.08 ± 48.02 pg/ml vs. 41.10 ± 27.34 pg/ml and 25.24 ± 30.28 pg/ml, P < 0.01) and TOF ones (55.14 ± 48.62 pg/ml vs. 31.84 ± 28.49 pg/ml and 19.94 ± 15.90 pg/ml, P < 0.05). Here, IL6 is linked to premature menopause.