Of the 10 patients with indeterminate T-Spot.TB, their median CD4 counts were 458.8 cells/μL (range, 0 to 934 cells/μL) and median plasma HIV RNA load 1.60 log10 copies/mL (range, 2 to 6 log10 copies/mL) at the time of T-Spot.TB testing; none had a history of TB. The gene discussed is CD4; the disease is tuberculosis.