De Chiara and colleagues (2010, 2013) found that in striatum, BDNF selectively antagonizes CB1R receptor function at inhibitory synapses in a cholesterol metabolism-mediated mechanism It has also been found that the neuroprotective effects of eCBs, particularly in depression and epileptic seizures, are mediated by changes in BDNF expression (Marsicano et al., 2003; Khaspekov et al., 2004; Aguado et al., 2007; Aso et al., 2008; Vinod et al., 2012). During interneuron differentiation, eCBs have additive effects with BDNF in regulating interneuron migration (Berghuis et al., 2005). Here, BDNF is linked to major depressive disorder.