IL6 and cancer: IL-6 transmits major survival signals through various pathways, including PI3K/AKT, Ras/Raf/MEK-ERK1/2, JAK/STAT3, SHP2/RAFTK, and Src-family tyrosine kinase pathways, and each of these pathways may give the cancer cell alternative surviving reliance other than original intrinsic mutation [63].