By transplanting LLC adenocarcinoma cells via tail vein injection to the mice with same genetic background (C57BL/6 mice) to mimic the original lung tumor environment, we found that lung cancer cells could secrete galectin-1 to affect the differentiation of monocyte into tolerogenic dendritic cells with increased production of IL-10 [42]. This evidence concerns the gene LGALS1 and lung carcinoma.