MUTYH and breast cancer: Out et al. found that minor allele genotypes of several MUTYH variants showed a trend towards association with lobular BC histology [14], while Rennert et al. found no differences for ductal or other BC histology type among 30 patients heterozygous for p.Gly396Asp or p.Tyr179Cys and 359 patients homozygous wild-type for these mutations [15].