INS and obesity due to melanocortin 4 receptor deficiency: Another study showed that mice treated with trans fats in a high-fat diet and high-fructose corn syrup in water, associated to sedentary behaviour, developed a severe phenotype of fatty liver disease with necroinflammatory changes and a profibrogenic response at the molecular level in the setting of obesity, hepatic IR, impaired insulin responsiveness and hyperinsulinemia.