Hypoadiponectinemia together with other cytokines, i.e. tumour necrosis factor-alpha (TNF-α) or plasminogen activator inhibitor-1 (PAI-1), induced by the accumulation of visceral adipose tissue (VAT) might be a major background of metabolic disorders, including insulin resistance (IR) and metabolic syndrome (MS) [3]. The gene discussed is SERPINE1; the disease is adiponectin deficiency.