Since bromocriptine can reverse insulin resistance, glucose intolerance and fattening by its i.c.v. injection, the present observed effects on hepatic glucose and lipid metabolism may be the indirect result of its treatment effects on the entire neuroendocrine axis, not only by influencing the VMH and SCN as described above and reducing neuropeptide Y and corticotropin levels in the paraventricular hypothalamus as previously described [45], and such is the topic of our ongoing investigation. The gene discussed is POMC; the disease is Insulin resistance.