It should be appreciated that while the small reduction in food consumption with bromocriptine treatment observed in this study may contribute to its overall effects on metabolic status, such small reductions (in low fat content food) are not large enough to explain the large reductions in body fat, liver fat, insulin resistance, or hypertension, and indeed previous studies have demonstrated improvements in insulin resistance and body fat of bromocriptine treated animals without any change in feeding [5, 6, 10]. Here, INS is linked to hypertensive disorder.