TNFAIP8 and neoplasm: In addition, the staining points of the normal tissue indicated no significant difference in the levels of TNFAIP8 between the T3+T4 and T1+T2 groups, however TNFAIP8 was upregulated in the tumor tissues from T3+T4 patients, compared with those from T1+T2 patients (Fig. 1Bf).