MFGE8 and Sepsis: In our previous studies, we observed a significant decrease in MFG-E8 expression in the immune reactive organs following sepsis, ALI and gut I/R injury, and exogenous treatment with recombinant murine MFG-E8 (rmMFG-E8) markedly improved survival by attenuating systemic inflammation and the infiltration of neutrophils at vital organs (8,9,33).