ADAMTS1 and Familial prostate cancer: It has been reported that the expression of ADAMTS1 is epigenetically silenced in non-small cell lung cancer (NSCLC) (25,32), prostate cancer (33) and colorectal tumor tissues (28,34), however, no significant association has been observed between hypermethylation and reduced expression of ADAMTS1 in colorectal tumor tissues (34).