Consistent with the impact of altered FOXM1 expression on the invasion of SW620 cancer cells in vitro, transwell invasion assay revealed that FoxM1 shRNA-transfected cells showed a low level of penetration through the Matrigel-coated membrane compared with the control cells (Figure 6C-right, D-lower, *** P < 0.001). Here, FOXM1 is linked to cancer.