The genetic syndromes such as familial breast cancer (BRCA2, BRCA1, and PALB2), the Peutz-Jeghers syndrome (LKB1/STK11), the familial atypical multiple mole melanoma (FAMMM) syndrome (p16/CDKN2A), hereditary pancreatitis (PRSS1), and the lynch syndrome (MLH1, MSH2, MSH6, PMS2) are also associated with an increased risk of developing PDAC [8,9]. This evidence concerns the gene STK11 and familial atypical multiple mole melanoma syndrome.