GPC1 and GPC6 were rarely seen in the intralesional stroma of oral cavity HNSCC lesions (13 out of 163 and 16 out of 163 of the cases, respectively), whereas GPC3 was consistently absent from this compartment and GPC4 showed a somewhat more frequent expression in stromal cells (19%; 31 out of 163 of the cases; Table 2; Figure 2). This evidence concerns the gene GPC3 and head and neck squamous cell carcinoma.