Previously documented, representative examples of the implication of diverse PGs expressions for disease outcome are afforded by the recently consolidated tumour-suppressing effect of GPC5 in lung carcinomas arising in “never smokers” [29-31], as well as by the well-established prognostic/predictive up-regulation of GPC1 in pancreatic cancer [32,33]. Here, GPC1 is linked to familial pancreatic carcinoma.