Indeed, in a study of patients recruited from allergy clinic in Italy, Scala et al41 analyzed IgE component results (from an earlier version of ISAC containing 73 allergen components) in more than 3000 patients with IgE reactivity to any member of 3 “panallergen” groups (tropomyosins, profilins, and pathogenesis-related class 10 proteins). The gene discussed is IGHE; the disease is allergic disease.