Inflammatory factors derive not only from the systemic reaction to malignancies, but also the secretion of tumor cells, including acute phase proteins like CRP, [18,19] chemokines [20], cytokines like interleukin 6 (IL-6) [21], transcription factor like NF-κB [22], circulating and infiltration immune cells [23] and so on. This evidence concerns the gene CRP and neoplasm.