Our study demonstrated that the CRP/Alb ratio was associated with some important clinicopathological characteristics in ESCC, including tumor size (P < 0.001), tumor differentiation (P = 0.019), T stage (P = 0.003), N stage (P = 0.015), M stage (P < 0.001) and TNM stage (P < 0.001). The gene discussed is CRP; the disease is esophageal squamous cell carcinoma.