KIF11 and primary lymphedema: These may be explained by several hypotheses: (1) Deletions or deep-intronic mutations in KIF11, which were not assessed in the study; (2) Somatic/mosaic KIF11 mutations that are not detectable in the blood by Sanger sequencing: mosaicism as a cause of MCLMR can be investigated by sequencing tissue and blood-DNA using targeted deep sequencing; (3) Existence of a mimicking disorder: many different genes can cause microcephaly, including those implicated in autosomal recessive primary microcephaly and syndromic microcephaly [25], or primary lymphedema [26].