Levels of THRα were found to be significantly decreased in breast cancer (n = 101, 0.90 (0.03) Log10 RQ) compared to both normal (n = 27, 1.50 (0.06) Log10 RQ, p < 0.001) and fibroadenoma tissues (n = 32, 1.28(0.07), p < 0.001, Additional file 2: Figure S2). This evidence concerns the gene THRA and Fibroadenoma.