IFNA1 and neoplasm: Notably, IFN-DCs exert a direct cytotoxic effect on tumor cells, [12] are capable to take up, through the scavenger receptor Lectin-like oxidized-LDL receptor-1 (LOX-1), apoptotic cells [17] and cross-present their antigens to CD8+ T cells, thus leading to an efficient cross-priming of these cells [18-20].