APOE and Parkinson disease: We and others have shown that in sporadic and familial PD, GBA mutations are associated with early-onset PD and may modify age at onset of PD[9,10] and that in brain autopsies GBA mutation status was significantly associated with the presence of cortical LB (OR = 6.48, 95% CI, 2.45–17.16, p<0.001) and a neuropathological diagnosis of DLB after adjusting for sex, age at death, and presence of APOE-4[11].