We also evaluated association of protective variants and observed association of variants in SMPD1 in LBD (p = 0.03) and ADLBV (p = 0.02), but not AD, and MCOLN1 variants in LBD (p = 0.02), ADLBV (p = 0.005) but not AD (Table 3). This evidence concerns the gene MCOLN1 and Alzheimer disease.