To determine whether variants in other lysosomal storage disease genes, in the same pathway as GBA, are associated with LBs we conducted an independent genetic study of the lysosomal storage disorder genes GBA, HEXA, SMPD1, and MCOLN1 in 231 brain autopsies from the New York Brain Bank at Columbia University. The gene discussed is HEXA; the disease is lysosomal storage disease.