Elevated plasma levels of VEGF have been found in patients with AML and CML, and increased bone marrow vasculature has especially been noted in CML.15 Furthermore, lower levels of VEGF at the diagnosis have been shown to be associated with better prognosis in CML.16 Recently axitinib was shown to possess high affinity to T315I-mutated BCR-ABL1,17 which may explain the high activity in patient sample 2. The gene discussed is VEGFA; the disease is chronic myelogenous leukemia, BCR-ABL1 positive.