MECOM and myeloid neoplasm: MOLM-1 is characterized as a mega-karyocytic cell line and in addition to the Ph chromosome with an e13-a2 BCR-ABL1 fusion gene, it carries the inv(3)(q21q26) chromosomal aberration, which leads to overexpression of ecotropic viral integration site 1 (EVI1) gene.7, 13 High EVI1 expression has been linked with poorer prognosis in myeloid malignancies and TKI resistance, which could be one explanation for poorer TKI sensitivity in MOLM-1 cells.14 Instead, MOLM-1 cells were highly sensitive to glucocorticoids, which has not been described previously.