Reduced renal function (eGFR<60 ml/min) was independently associated with a higher risk of developing HIV-related events (adjusted HR 2.49; 95%CI 1.56–3.97) in a multivariate model adjusted for baseline characteristics (age, gender, mode of HIV transmission, nationality and calendar year of baseline) but did not remain independently associated in a multivariate model adjusted for HIV-associated characteristics (ART-status, baseline CD4+ and CD8+ T cell count, nadir CD4+ T cell count, baseline HIV-RNA, co-infection with HBV/HCV). The gene discussed is CD4; the disease is coinfection.