In the current study, BBG, a P2X7 receptor antagonist as an “edible” blue dye significantly ameliorated the severity of portal-systemic shunting and mesenteric angiogenesis in CBDL rats, implying that P2X7 inhibition can be a candidate to control the complications associated with angiogenesis in cirrhosis. This evidence concerns the gene P2RX7 and Cirrhosis.